1, 4-Dibenzylpiperazines possess anticocaine activity

A Foster, H Wu, W Chen, W Williams, WD Bowen…

文献索引：Foster, Abby; Wu, Huifang; Chen, Weibin; Williams, Wanda; Bowen, Wayne D.; Matsumoto, Rae R.; Coop, Andrew Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 749 - 751

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被引用次数: 30

摘要

N, N-Dibenzylpiperazines have high affinity for sigma receptors, and we aimed to increase their anticocaine activity by introducing substituents known to enhance such activity in other sigma ligands. Ligands with high affinity for sigma-1 receptors resulted, but their activity in attenuating cocaine-induced convulsions did not correlate with sigma-1 binding affinity, and may be more closely related to their sigma-2 binding affinities.