Prostaglandin E 2-bisphosphonate conjugates: potential agents for treatment of osteoporosis

L Gil, Y Han, EE Opas, GA Rodan, R Ruel…

文献索引：Bioorganic and Medicinal Chemistry, , vol. 7, # 5 p. 901 - 919

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被引用次数: 86

摘要

... Bioorganic & Medicinal Chemistry. ... a Department of Medicinal Chemistry, Merck Frosst ... Unfortunately, such implants are impractical in a normal therapeutic setting and the pharmaceutical utility of systemic PGE 2 is greatly reduced due to side effects and metabolic instability. ...