Synthesis

Synthesis of homochiral 2-(2-arylethyl) piperazines

JM Schaus, JH Krushinski, KM Ruley, VP Rocco

文献索引：Schaus, John M.; Krushinski, Joseph H.; Ruley, Kevin M.; Rocco, Vincent P. Synthesis, 2007 , # 15 p. 2307 - 2312

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摘要

During the course of work to identify antipsychotic agents with improved efficacy and tolerability, [1] we determined that the 3′-phenethyl-substituted analogue of olanzapine (1, Ar = phenyl) possessed a desirable receptor binding profile (Figure [1] ). In order to study how modification of the pendant aromatic ring would affect the in vitro and in vivo activity of this series, we needed to prepare a series of analogues of structure 1 and consequently required access to a ...