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Discovery of S-[5-Amino-1-(4-fluorophenyl)-1 H-pyrazol-4-yl]-[3-(2, 3-dihydroxypropoxy) phenyl] methanone (RO3201195), an Orally Bioavailable and Highly …

DM Goldstein, T Alfredson, J Bertrand…

文献索引:Journal of Medicinal Chemistry, , vol. 49, # 5 p. 1562 - 1575

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被引用次数: 62

摘要

... Journal of Medicinal Chemistry. ... Chemistry. Two synthetic routes to the (5-amino-1-phenyl-1H-pyrazol-4-yl)phenylmethanone scaffold were developed (Schemes 1 and 2). The principle approach began with the corresponding ...