17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level

…, N Mehta, T Mukhopadhyay, A Kumar, M Kumar

文献索引：Dhingra, Neelima; Bhardwaj, Tilak Raj; Mehta, Neeraj; Mukhopadhyay, Tapas; Kumar, Ashok; Kumar, Manoj Medicinal Chemistry Research, 2011 ,  vol. 20,  # 7  p. 817 - 825

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被引用次数: 2

摘要

Abstract The 17-oximino-5-androsten-3β-yl esters (10a–10j) were synthesized from commercially available (25 R)-5-Spirosten-3β-ol (Diosgenin)(4) as starting material. The synthesized compounds were evaluated for their antiproliferative activity against prostate specific cancer cell line DU-145, acute toxicity, and effect on serum androgen level and were compared with Finasteride used as positive control. Some of the compounds exhibited ...