Phosphine-catalyzed reductions of alkyl silyl peroxides by titanium hydride reducing agents: Development of the method and mechanistic investigations

…, MT Haynes, AM Thomas, KA Woerpel

文献索引：Harris, Jason R.; Haynes, M. Taylor; Thomas, Andrew M.; Woerpel Journal of Organic Chemistry, 2010 ,  vol. 75,  # 15  p. 5083 - 5091

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被引用次数: 38

摘要

A method that allows for the reduction of protected hydroperoxides by employing catalytic amounts of phosphine is presented. The combination of a titanium (IV) alkoxide and a siloxane allowed for the chemoselective reduction of phosphine oxides in the presence of alkyl silyl peroxides. Subsequent reduction of the peroxide moiety by phosphine provided the corresponding silylated alcohols in useful yields. Mechanistic experiments, including ...