Cytotoxic and Apoptosis??Inducing Activities of Steviol and Isosteviol Derivatives against Human Cancer Cell Lines

…, S Sawada, T Kikuchi, Y Kushi, M Fukatsu…

文献索引：Ukiya, Motohiko; Sawada, Shingo; Kikuchi, Takashi; Kushi, Yasunori; Fukatsu, Makoto; Akihisa, Toshihiro Chemistry and Biodiversity, 2013 , vol. 10, # 2 p. 177 - 188

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被引用次数: 15

摘要

Abstract Seventeen steviol derivatives, ie, 2–18, and 19 isosteviol derivatives, ie, 19–37, were prepared from a diterpenoid glycoside, stevioside (1). Upon evaluation of the cytotoxic activities of these compounds against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3) cancer cell lines, nine steviol derivatives, ie, 5–9 and 11–14, and five isosteviol derivatives, ie, 28–32, exhibited activities with single-digit micromolar IC 50 ...