Structure stability/activity relationships of sulfone stabilized N, N-dichloroamines

…, DJR O'Mahony, N Alvarez, A Houchin, P Xu…

文献索引：Low, Eddy; Kim, Bum; Francavilla, Charles; Shiau, Timothy P.; Turtle, Eric D.; O'Mahony, Donogh J.R.; Alvarez, Nichole; Houchin, Ashley; Xu, Ping; Zuck, Meghan; Celeri, Chris; Anderson, Mark B.; Najafi, Ramin; Jain, Rakesh K. Bioorganic and Medicinal Chemistry Letters, 2011 ,  vol. 21,  # 12  p. 3682 - 3685

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摘要

Abstract Structure stability/activity relationships (SXR) of a new class of N, N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate ...