Topical nonsteroidal antipsoriatic agents. 2. 2, 3-(Alkylidenedioxy) naphthalene analogs of lonapalene

…, BE Loe, GH Jones, JM Young

文献索引：Venuti, Michael C.; Loe, Brad E.; Jones, Gordon H.; Young, John M. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 11  p. 2132 - 2136

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被引用次数: 30

摘要

A series of 2, 3-(alky1idenedioxy) naphthalene analogues (58-p) of lonapalene (RS-43179, l), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity against arachidonic acid induced mouse ear edema. The results of these studies demonstrate that introduction of the fused 2, 3-alkylidenedioxy ring, in place of the acyclic 2, 3-dialkoxy substituent pattern ...