Structure??Based Insight into the Asymmetric Bioreduction of the C C Double Bond of α, β??Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase
…, A Roujeinikova, D Leys, JM Gardiner…
文献索引：Toogood, Helen S.; Fryszkowska, Anna; Hare, Victoria; Fisher, Karl; Roujeinikova, Anna; Leys, David; Gardiner, John M.; Stephens, Gill M.; Scrutton, Nigel S. Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2789 - 2803
Abstract Biocatalytic reduction of α-or β-alkyl-β-arylnitroalkenes provides a convenient and efficient method to prepare chiral substituted nitroalkanes. Pentaerythritol tetranitrate reductase (PETN reductase) from Enterobacter cloacae st. PB2 catalyses the reduction of nitroolefins such as 1-nitrocyclohexene (1) with steady state and rapid reaction kinetics comparable to other old yellow enzyme homologues. Furthermore, it reduces 2-aryl-1- ...
