Abstract The three possible mono-O-methyl derivatives of 6-chloro-2, 3, 4, 5-tetrahydro-1-(4- hydroxyphenyl)-1H-3-benzazepin-7, 8-diol (SK&F 82526)(1) have been synthesized to facilitate the isolation and characterization of metabolites of this compound and for biological testing. The syntheses generally involved preparation of appropriately substituted benzaldehydes, conversion of these to phenylacetic acids and use of these to N-acylate ...
