Chemical Synthesis and Biological Evaluation of Second??Generation Palmerolide A Analogues
VR Ravu, GYC Leung, CS Lim, SY Ng…
文献索引：Ravu, Vengala Rao; Leung, Gulice Y. C.; Lim, Chek Shik; Ng, Sin Yee; Sum, Rong Ji; Chen, David Y.-K. European Journal of Organic Chemistry, 2011 , # 3 p. 463 - 468
Abstract In this communication, second-generation analogues of palmerolide A, a recently reported cytotoxic agent against melanoma cancer cells, were rationally designed, synthesized, and biologically evaluated. Structural variations of the enamide side chain and the C1–C8 segment of palmerolide A revealed a narrow structure–activity relationship window of the newly synthesized compounds. In addition, mechanistic and ...
