Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

B Charpentier, JM Bernardon, J Eustache…

文献索引：Charpentier; Bernardon; Eustache; Millois; Martin; Michel; Shroot Journal of Medicinal Chemistry, 1995 ,  vol. 38,  # 26  p. 4993 - 5006

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被引用次数: 130

摘要

Retinoids, natural and synthetic analogues of vitamin A, play a major role in controlling cell proliferation and differentiation. These properties confer on this class of substances a high potential for the treatment of various hyperproliferative diseases. 2 all-trans-Retinoic acid (AtRA), 13-cis-retinoic acid, and synthetic analogues are widely used by both the topical and oral routes of administration in the management of dermatological diseases such as acne, ...