Stereoselective Synthesis of D-Erythrose and D-Threose Derivatives from D-Glyceraldehyde Acetonide and Their Reactions with 1-(Trimethylsilyl) vinyl Cuprate …
A new and efficient route to the synthesis of trialkoxy derivatives of D-erythrose (1) and D- threose from readily available D-glyceraldehyde acetonide was developed. The addition reaction of 1 with 1-(trimethylsilyl) vinyl cuprate reagent proceeded highly stereoselectively to afford anti addition product, which was then readily converted into allitol hexaacetate.
