Convergent and Selective Synthesis of Pyrrolidinones, Piperidinones, Dihydropyridinones and Pyridinols from a Common Intermediate–Potential Precursors of …
M Jida, J Ollivier
文献索引：Jida, Mouhamad; Ollivier, Jean European Journal of Organic Chemistry, 2008 , # 23 p. 4041 - 4049
Abstract Titanium-mediated cyclopropanation of natural and unnatural β-amino acid derivatives provides azabicyclo [3.1. 0] hexan-1-ols as mixtures of diastereomers that are separable by silica-gel chromatography. Depending on the ring cleavage procedure employed, these compounds lead efficiently to diverse intermediates for the synthesis of pharmaceuticals. Thus, depending on the experimental conditions, basic treatment can ...
