Tetrahedron

Synthesis of a dinucleoside 3′-S-phosphorothiolate containing 2′-deoxy-3′-thioadenosine

X Li, DM Andrews, R Cosstick

文献索引：Li, Xiang; Andrews, David M.; Cosstick, Richard Tetrahedron, 1992 ,  vol. 48,  # 13  p. 2729 - 2738

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被引用次数: 22

摘要

2′-Deoxy-3′-thio-5′-O-(4-monomethoxytrityl)-6-N-benzoyladenosine (1a) has been prepared from adenosine in seven steps and, following conversion of to a 3′-S- phosphorothioamidite, used to synthesize a dinucleoside 3′-S-phosphorothiolate containing 2′-deoxy-3′-thioadenosine. The procedure is compatible with automated methods of DNA synthesis and extends the potential of the recently developed ...