The directed ortho-lithiation-alkylation of several tertiary@-amino benzamides was studied. The orthosubstituted@-amino benzamides were hydrolyzed directly with 6 N hydrochloric acid, or by a three-step, one-pot reaction involving methylation, elimination, and treatment with aqueous acid. o-Toluic acid, 2-n-butylbenzoic acid, 2-methoxy-6-methylbenzoic acid, and 4-methoxy-2-methylbenzoic acid were prepared by using this ortho-metalation- ...
![o-methyl-N-[2-(diethylamino)ethyl]-N-ethylbenzamide结构式](https://image.chemsrc.com/caspic/010/103562-85-2.png)