cussed herein. The procedure of Gialdi et al. 6 was modified slightly to give 4 in nearly quantitative yields. The yield of the ester acid 6, despite varied attempts, never exceeded the stastically expected 50%. The preparation of the amido esters 7 and their reduction to the amino alcohols 8 proceeded without difficulty. Ring closure to the thiazocinium tosylates was achieved at room temperature within 3 h. Even at 0 “C, the reaction was complete within a ...
