Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents

…, T Harasaki, T Fukuoka, S Kaneko, T Konosu

文献索引：Arai, Masami; Harasaki, Tamako; Fukuoka, Takashi; Kaneko, Satoru; Konosu, Toshiyuki Bioorganic and Medicinal Chemistry Letters, 2002 ,  vol. 12,  # 19  p. 2733 - 2736

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被引用次数: 9

摘要

N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-d- proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25–2 μg/mL.