Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site

Y Abe, O Nakagawa, R Yamaguchi, S Sasaki

文献索引：Abe, Yukiko; Nakagawa, Osamu; Yamaguchi, Rie; Sasaki, Shigeki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3470 - 3479

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被引用次数: 5

摘要

DNA is continuously damaged by endogenous and exogenous factors such as oxidative stress or DNA alkylating agents. These damaged nucleobases are removed by DNA N- glycosylase and form apurinic/apyrimidinic sites (AP sites) as intermediates in the base excision repair (BER) pathway. AP sites are also representative DNA damages formed by spontaneous hydrolysis. The AP sites block DNA polymerase and a mismatch nucleobase ...