Tetrahedron letters

Vitamin D heterocyclic analogues. Part 1: A stereoselective route to CD systems with pyrazole rings in their side chains

Y Fall, C Barreiro, C Fernández, A Mouriño

文献索引：Fall, Yagamare; Barreiro, Candida; Fernandez, Carlos; Mourino, Antonio Tetrahedron Letters, 2002 ,  vol. 43,  # 8  p. 1433 - 1436

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被引用次数: 10

摘要

In most potentially applicable vitamin D analogues it is the side chain of 1 that is modified (although only a few of the numerous analogues of this type that have been synthesized in recent decades have in fact proved useful for the treatment of cancers 1. and 2. or psoriasis 3., and ). In particular, analogues with rigid, conformationally restricted structural units in the side chain tend to combine non-negligible antiproliferative activity with low calcaemic activity. 4., and ...