Helvetica chimica acta

Pteridines. Part LXXXV. Chemical synthesis of deoxysepiapterin and 6??acylpteridines by acyl radical substitution reactions

R Baur, T Sugimoto, W Pfleiderer

文献索引：Baur, Ralph; Sugimoto, Takashi; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1988 ,  vol. 71, p. 531 - 543

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被引用次数: 21

摘要

Abstract A new synthesis of deoxysepiapterin (2), one of the two yellow eye pigments of the Drosophila mutant sepia, is described. The synthetic approach makes use of a homolytic nucleophilic acylation of 7-(alkylthio) pteridine derivatives (11, 13, 15, 18, 20) leading to the corresponding 6-acyl derivatives (21–27). Desulfurizations have been achieved for the first time in the pteridine series using Raney-Co, Raney-Cu, or Cu [BOND] Al alloy in alkaline ...