Tetrahedron Letters

Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology

DP Pienaar, RK Mitra, TI van Deventer, AL Botes

文献索引：Pienaar, Daniel P.; Mitra, Robin K.; Deventer, Thomas I. van; Botes, Adriana L. Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6752 - 6755

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被引用次数: 7

摘要

Novel epoxide hydrolases in Yarrowia lipolytica have been shown to hydrolyse a variety of functionalised epoxides with good to excellent stereoselectivity and at high volumetric productivities. Individual biotransformation products have been converted into optically active (R)-(tetrahydrofuran-2-yl) methanol (6),(S)-N-benzyl-3-hydroxypyrrolidine (7),(S)-3- hydroxytetrahydrothiophene (8),(S)-N-benzyl-3-acetoxypiperidine (10),(S)-3- ...