5′-Alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity

…, M Kessler, R Granger, G Lynch, AR Chamberlin

文献索引：Phillips, Dean; Sonnenberg, Jennifer; Arai, Amy C; Vaswani, Rishi; Krutzik, Peter O; Kleisli, Thomas; Kessler, Markus; Granger, Richard; Lynch, Gary; Richard Chamberlin Bioorganic and medicinal chemistry, 2002 ,  vol. 10,  # 5  p. 1229 - 1248

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被引用次数: 52

摘要

AMPA receptors form a major subdivision of the glutamate receptor family that mediates excitatory synaptic transmission in the brain. Currents through AMPA receptors can be up-or down-regulated by compounds that allosterically modulate receptor kinetics through binding sites distinct from that for glutamate. One of those modulators is the benzothiadiazide IDRA- 21 which has been reported to enhance synaptic transmission and be effective in ...