Regioselective C2-arylation of imidazo [4, 5-b] pyridines

J Macdonald, V Oldfield, V Bavetsias…

文献索引：Macdonald, Jonathan; Oldfield, Victoria; Bavetsias, Vassilios; Blagg, Julian Organic and Biomolecular Chemistry, 2013 , vol. 11, # 14 p. 2335 - 2347

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被引用次数: 12

摘要

We show that N3-MEM-protected imidazo [4, 5-b] pyridines undergo efficient C2- functionalisation via direct C–H arylation. Twenty-two substituted imidazo [4, 5-b] pyridines are prepared and iterative, selective elaboration of functionalised imidazo [4, 5-b] pyridines gives 2, 7-and 2, 6-disubstituted derivatives in goo