Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors

…, W Subotkowski, W Tomasik, BJ Vanasse…

文献索引：Weiberth, Franz J.; Gill, Harpal S.; Jiang, Ying; Lee, George E.; Lienard, Philippe; Pemberton, Clive; Powers, Matthew R.; Subotkowski, Witold; Tomasik, Witold; Vanasse, Benoit J.; Yu, Yong Organic Process Research and Development, 2010 , vol. 14, # 3 p. 623 - 631

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被引用次数: 6

摘要

Sodium-glucose transporters (SGLT) are a family of proteins that have an important role in transporting glucose across cellular membranes against a concentration gradient. These proteins are predominantly expressed in intestinal mucosa (SGLT1) and kidney tubules (SGLT1 and SGLT2) where they mediate intestinal absorption and renal reabsorption of glucose.(1) SAR7226 (1) emerged as a promising SGLT1/SGLT2 inhibitor, potentially useful for the treatment of diabetes,(2) ...