Synthesis and in-vivo evaluation of [11C] p-PVP-MEMA as a PET radioligand for imaging nicotinic receptors

…, B Lagnel-de Bruin, DJ Henderson, F Hinnen…

文献索引：Dolle, Frederic; Langle, Sandrine; Roger, Gaelle; Fulton, Roger R.; Lagnel-De Bruin, Beatrice; Henderson, David J.; Hinnen, Francoise; Paine, Taliesha; Coster, Mark J.; Valette, Heric; Bottlaender, Michel; Kassiou, Michael Australian Journal of Chemistry, 2008 , vol. 61, # 6 p. 438 - 445

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被引用次数: 4

摘要

Abstract Within the class of (4-pyridinyl) vinylpyridines developed by Abbott laboratories as potent neuronal nicotinic acetylcholine receptor ligands, p-PVP-MEMA ({(R)-2-[6-chloro-5- ((E)-2-pyridin-4-ylvinyl) pyridin-3-yloxy]-1-methylethyl} methylamine) is the lead compound of a novel series that do not display the traditional nicotinic-like pyrrole-ring but still possessing high subnanomolar affinity (K i 0.077 nm—displacement of [3 H](–) cytisine ...