… activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1- …

…, Y Nakamura, M Ishii, K Hirotani, E Kumazawa…

文献索引：Naito, Hiroyuki; Ohsuki, Satoru; Sugimori, Masamichi; Atsumi, Ryo; Minami, Megumi; Nakamura, Yoshihide; Ishii, Mineko; Hirotani, Kenji; Kumazawa, Eiji; Ejima, Akio Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 4 p. 453 - 462

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被引用次数: 19

摘要

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1- piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propene (2) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines in vitro and antitumor activity against some tumor models when dosed both intraperitoneally and ...