Synthesis, physical–chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4 (1H)-ones: Iron chelators with the potential for treating …
A Gaeta, F Molina-Holgado, XL Kong, S Salvage…
文献索引：Gaeta, Alessandra; Molina-Holgado, Francisco; Kong, Xiao L.; Salvage, Sarah; Fakih, Sarah; Francis, Paul T.; Williams, Robert J.; Hider, Robert C. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1285 - 1297
A novel class of 2-amido-3-hydroxypyridin-4-one iron chelators is described. These compounds have been designed to behave as suitable molecular probes which will improve our knowledge of the role of iron in neurodegenerative conditions. Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson disease (PD), can be considered as diverse pathological conditions sharing critical metabolic processes such ...
