Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed Dehydrogenation of Alcohols

H Xie, S Zhang, H Li, X Zhang, S Zhao…

文献索引：Xie, Hexin; Zhang, Shilei; Li, Hao; Zhang, Xinshuai; Zhao, Sihan; Xu, Zian; Song, Xixi; Yu, Xinhong; Wang, Wei Chemistry - A European Journal, 2012 , vol. 18, # 8 p. 2230 - 2234

全文：HTML全文

被引用次数: 21

摘要

As an iconic polyene natural product, dihydroxerulin (1)[1] has received considerable interest from the synthetic community (Scheme 1).[2] In addition to its intriguing biological properties as a potent noncytotoxic inhibitor of the biosynthesis of cholesterol,[1] the conjugated polyene consists of a unique combination of alkene, alkyne, and butenolide units. Therefore, it has served as a platform for developing synthetic strategies for polyene ...