Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids

H Kagechika, E Kawachi, Y Hashimoto…

文献索引：Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 834 - 840

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被引用次数: 79

摘要

The structureactivity relationships of (E)-chalcone-4-carboxylic acids, which are retinoidal benzoic acids represented by R-Ph-X-Ph-COOH (4, X=-COCH= CH--), are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60. ...