Tetrahedron letters

Direct thiophene arylation catalysed by palladium

C Gozzi, L Lavenot, K Ilg, V Penalva, M Lemaire

文献索引：Gozzi, Christel; Lavenot, Laurence; Ilg, Kerstin; Penalva, Vincent; Lemaire, Marc Tetrahedron Letters, 1997 , vol. 38, # 51 p. 8867 - 8870

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被引用次数: 93

摘要

Direct thiophene arylation using a Heck-type reaction with Pd (OAc) 2NBu 4Br as catalytic system is reported. Reactions with 2-and 3-substituted thiophenes have shown that substituent nature and position influence the cross-coupling. In particular, the substitution is regiospecific when the heterocycle is 2-substituted with an electron withdrawing group.