Benzoylphosphonate??Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains

A Horatscheck, S Wagner, J Ortwein…

文献索引：Horatscheck, Andre; Wagner, Stefan; Ortwein, Jutta; Kim, Boo Geun; Lisurek, Michael; Beligny, Samuel; Schuetz, Anja; Rademann, Joerg Angewandte Chemie - International Edition, 2012 , vol. 51, # 37 p. 9441 - 9447 Angew. Chem., 2012 , vol. 124, # 37 p. 9577 - 9783,7

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被引用次数: 6

摘要

The phosphorylation of tyrosine residues is an important posttranslational modification of proteins and regulates the activity of numerous signal transduction pathways, for example, in highly proliferating cells. Phosphotyrosine residues are located on membrane receptors,[1] adaptor proteins,[2] enzymes,[3] and transcription factors.[4] They are recognized by protein tyrosine phosphatases (PTPs) and phosphotyrosine binding domains exemplified by the ...