Tetrahedron Letters

Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

T Chen, Q Huang, Y Luo, Y Hu, W Lu

文献索引：Chen, Taijie; Huang, Qingqing; Luo, Yu; Hu, Youhong; Lu, Wei Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1401 - 1404

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被引用次数: 4

摘要

A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin-2-ones with a series of arylboronic acids, using Cu (OTf) 2 as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O- arylated pyridin-2-ones with good selectivity and yields