Efficient synthesis of novel NK1 receptor antagonists: selective 1, 4-addition of grignard reagents to 6-chloronicotinic acid derivatives

…, H Hilpert, M Scalone, P Waldmeier

文献索引：Takahashi, Yukio; Yoneda, Norihiko Synthetic Communications, 1989 , vol. 19, # 11-12 p. 1945 - 1954

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被引用次数: 29

摘要

... Volume: Page: ... 1 , NK 2 , and NK 3 . The endogenous ligand for the NK 1 receptors is the 11 amino acid neuropeptide substance P. 1 Following ... By this approach, 1 was prepared in five linear steps with an overall yield of 19% and 2 and 3 were prepared in nine ...