Tetrahedron letters

A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes

H Fujioka, K Murai, Y Ohba, A Hiramatsu, Y Kita

文献索引：Fujioka, Hiromichi; Murai, Kenichi; Ohba, Yusuke; Hiramatsu, Atsushi; Kita, Yasuyuki Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2197 - 2199

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被引用次数: 112

摘要

The importance of dihydroimidazole units especially in biochemistry is recently increasing, since they are found in many biologically active compounds. 1 They are also used in organic synthesis as synthetic intermediates, 2 chiral auxiliaries, 3 and chiral ligands. 4 Therefore, several methodologies for synthesizing them have already been developed, mainly using nitriles 5 and esters 6 as the starting substrates. However, these previous methods have several drawbacks, namely ...