Synthesis and β-glucuronidase inhibitory potential of benzimidazole derivatives

…, S Naureen, S Perveen, M Iqbal Choudhary…

文献索引：Khan, Khalid Mohammed; Khan, Momin; Ambreen, Nida; Rahim, Fazal; Naureen, Shagufta; Perveen, Shahnaz; Choudhary, M. Iqbal; Voelterc, Wolfgang Medicinal Chemistry, 2012 , vol. 8, # 3 p. 421 - 427

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被引用次数: 9

摘要

Benzimidazole derivatives 1-24 have been synthesized and their in vitro β-glucuronidase inhibitory activitiy was evaluated. Compounds 15 (IC50= 6.33±0.40 μM), 7 (IC50= 22.0±0.33 μM), 2 (IC50= 23.1±1.78 μM), 17 (IC50= 23.9±1.46 μM), and 3 (IC50= 33.8±1.61 μM) showed more potent β-glucuronidase inhibitory activity than the standard (D-saccharic acid 1, 4 lactone, IC50= 48.4±1.25 μM). This study has identified a new series of potential β- ...