One-pot conversion of β-aminocrotononitrile to secondary enaminonitriles including chiral ones Application to synthesis

…, SKD Chowdhury, KK Mahalanabis

文献索引：Chatterjee; Mishra; Dutta Chowdhury; Mahalanabis, Kumar K. Canadian Journal of Chemistry, 2005 , vol. 83, # 8 p. 1164 - 1170

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被引用次数: 3

摘要

A highly efficient one-pot conversion of β-aminocrotononitrile to secondary enaminonitriles including chiral ones is described. In contrast to β-aminocrotononitrile, some of these N- substituted β-enaminonitriles on reacting with acid chlorides show a unique preference for C- terminal selection allowing preparation of pyrazoles without separation of regioisomers. In addition, use of secondary enaminonitriles also provided access to pyrazoles that are not ...