N-nitrosoanilines: a new class of caspase-3 inhibitors

Z Guo, M Xian, W Zhang, A McGill, PG Wang

文献索引：Guo, Zhengmao; Xian, Ming; Zhang, Wei; McGill, Andrea; Wang, Peng George Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 99 - 106

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被引用次数: 34

摘要

Caspases are a family of cysteine proteases activated during apoptosis. In cultured human endothelial cells, physiological levels of NO prevent apoptosis and interfere with the activation of the caspase cascade. Previous studies have demonstrated that NO inhibits the activity of caspase-3 by S-nitrosylation of the enzyme. In this study, the inhibitory effect of a new class of NO donors, N-nitrosoaniline derivatives, were examined against caspase-3. ...