Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

…, TW Lien, TA Hsu, CL Huang, HY Tseng, CC Lin…

文献索引：Li, Wen-Tai; Hwang, Der-Ren; Song, Jen-Shin; Chen, Ching-Ping; Chen, Tung-Wei; Lin, Chi-Hung; Chuu, Jiunn-Jye; Lien, Tzu-Wen; Hsu, Tsu-An; Huang, Chen-Lung; Tseng, Huan-Yi; Lin, Chu-Chung; Lin, Heng-Liang; Chang, Chung-Ming; Chao, Yu-Sheng; Chen, Chiung-Tong Investigational New Drugs, 2012 , vol. 30, # 1 p. 164 - 175

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被引用次数: 6

摘要

Summary Designed from a high throughput screened hit compound, novel 2-amino-1- thiazolyl imidazoles were synthesized and demonstrated cytotoxicity against human cancer cells. 1-(4-Phenylthiazol-2-yl)-4-(thiophen-2-yl)-1 H-imidazol-2-amine (compound 2), a 2- ...