5??Halobenzothiophene Analogues of Melatonin: Synthesis and Affinity for mt1 and MT2 Receptors in Man

…, C Bennejean, P Delagrange, J Boutin…

文献索引：Leclerc; Beaurain; Depreux; Bennejean; Delagrange; Boutin; Lesieur Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 61 - 65

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被引用次数: 5

摘要

Abstract A novel series of melatonin analogues based on the benzothiophene nucleus is described. In these compounds the methoxy group was replaced by electron-attracting groups such halogens (Br and Cl) with the aim of supplementing structure-affinity relationships on melatoninergic ligands. Target derivatives were prepared from the corresponding 4-halo-thiophenol. Some of these derivatives had high affinity for mt 1 and ...