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N-Arylbenzamides: extremely simple scaffolds for the development of novel estrogen receptor agonists

…, P Minazzi, PL Canonico, AA Genazzani…

文献索引:Caldarelli, Antonio; Minazzi, Paolo; Canonico, Pier Luigi; Genazzani, Armando A.; Giovenzana, Giovanni B. Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 1 p. 148 - 152

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被引用次数: 2

摘要

The research of estrogen receptor (ER) ligands has benefited in the last decade from the implementation of combinatorial chemistry. The general pharmacophore has been identified and subsequently a multitude of compounds have been synthesized. Surprisingly, up to now simple amides have not been taken into consideration. Here we show that amides resulting from the condensation of hydroxybenzoic acids with aminophenols result in compounds ...