Design, synthesis and investigation on the structure–activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents

…, B Wan, S Cho, SG Franzblau, G Costantino

文献索引：Pieroni, Marco; Wan, Baojie; Cho, Sanghyun; Franzblau, Scott G.; Costantino, Gabriele European Journal of Medicinal Chemistry, 2014 , vol. 72, p. 26 - 34

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被引用次数: 20

摘要

Abstract Tuberculosis (TB) is one of the deadliest infectious diseases of all times, and its recent resurgence is a supreme matter of concern. Co-infection with HIV and, in particular, the continuous isolation of new resistant strains, makes the discovery of novel anti-TB agents a strategic priority. The research of novel agents should be driven by the accessibility of the synthetic procedure and, in particular, by the lack of cross-resistance with the drugs ...