Process development on the enantioselective enzymatic hydrolysis of S-ethyl 2-ethoxy-3-(4-hydroxyphenyl) propanoate

…, PR Østergaard, E Marcussen, S Ebdrup

文献索引：Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88

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被引用次数: 24

摘要

A novel biocatalytic approach for the large-scale production of S-2-ethoxy-3-(4- hydroxyphenyl) propanoic acid S-1 from its racemic ethylester rac-2 by enantioselective hydrolysis has been developed. S-1 is an important building block in the synthesis of PPARα and-γ agonists such as Ragaglitazar [NNC 61-0029 ((-) DRF2725)]. The development history comprises enzyme screening, biocatalyst and process optimization, and scale-up ...