Organic letters

Synthesis of the parent and substituted tetracyclic ABCD ring cores of camptothecins via 1-(3-aryl-2-propynyl)-1, 6-dihydro-6-oxo-2-pyridinecarbonitriles

W Dai, JL Petersen, KK Wang

文献索引：Li, Hongbin; Yang, Hua; Petersen, Jeffrey L.; Wang, Kung K. Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4500 - 4508

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被引用次数: 23

摘要

A new synthetic pathway to the parent and substituted ABCD ring cores of the camptothecin family of alkaloids was developed. The N-alkylation of 1, 6-dihydro-6-oxo-2- pyridinecarbonitrile (2) with 3-bromo-1-phenylpropyne provided 3a using Curran's protocol.