Synthesen in der Isochinolinreihe: Zur Ätherspaltung 6, 7, 8-trimethoxy-substituierter Isochinolinverbindungen mit wässeriger Salzsäure

A Brossi, M Baumann, R Borer

文献索引：Brossi,A. et al. Monatshefte fuer Chemie, 1965 , vol. 96, p. 25 - 36

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被引用次数: 8

摘要

Abstract Treatment of the 6, 7, 8-trimethoxy-substituted 1, 2, 3, 4-tetrahydroisoquinoline I with 20% aqueous HCl yields predominantly the corresponding 6, 7, 8-trihydroxy derivative II. The analogously substituted 3, 4-dihydroisoquinoline IV and isoquinoline XXI are converted into their 6, 8-dimethoxy-7-hydroxy derivatives V and XXII under these conditions. The constitution of these phenols was established by synthesis and degradation.