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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

… and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl] methyl] benzamide …

…, T Morie, T Kon, N Yoshida, T Karasawa…

文献索引：Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624

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被引用次数: 45

摘要

The title compounds (19-55) with a 4-substituted 2-(aminomethy1) morpholine group were prepared and evaluated for the gastrokinetic activity by determining their effect on gastric emptying of phenol red semisolid meal in rats. Introduction of chloro, fluoro, and trifluoromethyl groups to the benzyl group of the parent compounds la and lb enhanced the activity. Among compounds tested, 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- ...

N-[(4-benzylmorpholin-2-yl)methyl]acetamide结构式

N-[(4-benzylmor...

~%

C-[4-(3,4-二氯-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3,4-二氯-苄基...

(2-(acetylamino)methyl)morpholine acetyl salt结构式

(2-(acetylamino...

~%

C-[4-(3,4-二氯-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3,4-二氯-苄基...

N-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)acetamide结构式

N-((4-(3,4-dich...

~%

C-[4-(3,4-二氯-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3,4-二氯-苄基...

N-[(4-benzylmorpholin-2-yl)methyl]acetamide结构式

N-[(4-benzylmor...

~%

C-[4-(4-甲氧基-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(4-甲氧基-苄基)...

(2-(acetylamino)methyl)morpholine acetyl salt结构式

(2-(acetylamino...

~%

C-[4-(4-甲氧基-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(4-甲氧基-苄基)...

2-Acetylaminomethyl-4-(p-methoxybenzyl)morpholine结构式

2-Acetylaminome...

~%

C-[4-(4-甲氧基-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(4-甲氧基-苄基)...

N-[(4-benzylmorpholin-2-yl)methyl]acetamide结构式

N-[(4-benzylmor...

~%

C-[4-(3-氟-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3-氟-苄基)-吗...

(2-(acetylamino)methyl)morpholine acetyl salt结构式

(2-(acetylamino...

~%

C-[4-(3-氟-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3-氟-苄基)-吗...

N-((4-(3-fluorobenzyl)morpholin-2-yl)methyl)acetamide结构式

N-((4-(3-fluoro...

~%

C-[4-(3-氟-苄基)-吗啉-2-基]-甲胺双盐酸盐结构式

C-[4-(3-氟-苄基)-吗...

4-乙酰氨基-5-氯-2-乙氧基苯甲酸甲酯结构式

4-乙酰氨基-5-氯-2-乙氧...

~97%

4-氨基-5-氯-2-乙氧基苯甲酸结构式

4-氨基-5-氯-2-乙氧基苯甲酸

N-[(4-benzylmorpholin-2-yl)methyl]acetamide结构式

N-[(4-benzylmor...

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

4-乙酰氨基水杨酸甲酯结构式

4-乙酰氨基水杨酸甲酯

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

4-乙酰氨基-5-氯-2-乙氧基苯甲酸甲酯结构式

4-乙酰氨基-5-氯-2-乙氧...

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

乙氧酰胺苯甲酯结构式

乙氧酰胺苯甲酯

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

2-[(acetylamino)methyl]-4-[3-(trifluoromethyl)benzyl]morpholine结构式

2-[(acetylamino...

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

(2-(acetylamino)methyl)morpholine acetyl salt结构式

(2-(acetylamino...

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

4-氨基-5-氯-2-乙氧基苯甲酸结构式

4-氨基-5-氯-2-乙氧基苯甲酸

未登录结构式

~%

4-amino-5-chloro-2-ethoxy-N-[[4-[[3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methyl]benzamide结构式

4-amino-5-chlor...

N-[(4-benzylmorpholin-2-yl)methyl]acetamide结构式

N-[(4-benzylmor...

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

4-乙酰氨基水杨酸甲酯结构式

4-乙酰氨基水杨酸甲酯

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

4-乙酰氨基-5-氯-2-乙氧基苯甲酸甲酯结构式

4-乙酰氨基-5-氯-2-乙氧...

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

乙氧酰胺苯甲酯结构式

乙氧酰胺苯甲酯

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

N-((4-(4-chlorobenzyl)morpholin-2-yl)methyl)acetamide结构式

N-((4-(4-chloro...

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

(2-(acetylamino)methyl)morpholine acetyl salt结构式

(2-(acetylamino...

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...

4-氨基-5-氯-2-乙氧基苯甲酸结构式

4-氨基-5-氯-2-乙氧基苯甲酸

C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE结构式

C-[4-(4-CHLORO-...

~%

4-amino-5-chloro-N-[[4-[(4-chlorophenyl)methyl]morpholin-2-yl]methyl]-2-ethoxybenzamide结构式

4-amino-5-chlor...