DXR inhibition by potent mono-and disubstituted fosmidomycin analogues

…, BR Srinivasa, M Larhed, TA Jones…

文献索引：Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin; Bjoerkelid, Christofer; Larsson, Anna M.; Suresh, Surisetti; Iyer, Harini; Srinivasa, Bachally R.; Bergfors, Terese; Unge, Torsten; Mowbray, Sherry L.; Larhed, Mats; Jones, T. Alwyn; Karlen, Anders Journal of Medicinal Chemistry, 2011 , vol. 54, # 14 p. 4964 - 4976

全文：HTML全文

被引用次数: 18

摘要

The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs from the classical mevalonate pathway that is essential in humans. Using a ...