Bis (phenazine-1-carboxamides): Structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs

JA Spicer, SA Gamage, GW Rewcastle…

文献索引：Rewcastle, Gordon W; Denny, William A Synthetic Communications, 1987 , vol. 17, # 10 p. 1171 - 1180

全文：HTML全文

被引用次数: 65

摘要

Ring-substituted bis (phenazine-1-carboxamides), linked by a-(CH2) 3NMe (CH2) 3-chain, were prepared from the corresponding substituted phenazine-1-carboxylic acids by reaction of the intermediate imidazolides with bis (3-aminopropyl) methylamine. The compounds