Synthesis And Antimicrobial Evaluation Of Oxazole-2 (3h)-Thione And 2-Alkylsulfanyl-1, 3-Oxazole Derivatives

S Silva, FVM Silva, J Justino, AP Rauter, P Rollin…

文献索引：Silva, Sandrina; Silva, Filipa V. M.; Justino, Jorge; Rauter, Amelia Pilar; Rollin, Patrick; Tatibouet, Arnaud Heterocycles, 2014 , vol. 88, # 2 p. 1013 - 1028

全文：HTML全文

被引用次数: 1

摘要

Abstract–The preparation of oxazole-2 (3H)-thiones (OXTs) by condensation of thiocyanic acid on α-hydroxycarbonyl substrates has been revisited. Extension to more complex scaffolds afforded chiral OXTs, whereas carbohydrate-fused 2-alkylsulfanyl-1, 3-oxazolines led to original hemiaminal structures. A survey of the reactivity of OXTs with various electrophiles showed S-or N-chemoselectivity based on HSAB parameters. Antimicrobial ...